séminaire "Matière molle et complexe": Angelina Angelova

Angelina Angelova (Institut Galien Paris-Sud) donnera un séminaire intitulé : "Liquid Crystalline Nanoassemblies for Delivery of Bioactive Molecules towards Neuroregeneration"

Self-assembled nanomaterials are attracting considerable interest in therapeutic innovation. Our research on lipid-based nanocarriers of liquid crystalline inner organization has been inspired by
the compartmentalization of biological systems and the formation of cubic and tubular membrane architectures in diverse cells and organelles. Self-assembly of lipid mixtures in aqueous medium
may generate a variety of mesophases (lamellar, inverted hexagonal, bicontinuous cubic, sponge, and intermediate type of structures). The topology of the liquid crystalline nanoassemblies governs
their controlled release properties for encapsulated drugs. We designed self-assembled mesoporous type carriers with incorporated functionalities in view of the necessity of targeting of receptor
proteins implicated in neurodegenerative diseases. Our research aims at understanding of the mechanism and dynamics of formation of the nanocarriers generated by amphiphilic building blocks
and time-resolved structural studies of the assembly and loading of therapeutic biomacromolecules [1-6].
It is of interest that the lipid bilayer building blocks impart biocompatible properties and low toxicity of the resulting nanoassemblies, which should provide minimal side effects in clinical
applications. Moreover, liquid crystalline assemblies generated by functionalized lipid systems display stimulus-responsive properties, which may expand the possible therapeutic approaches. Loading of guest biomacromolecules (peptide, proteins, or DNA) is associated with concentration-dependent lyotropic phase transitions in the host lipid systems. High resolution SAXS structural analysis was employed to monitor these effects. Upload of the neurotrophic protein BDNF (brain-derived neurotrophic factor) into lipid membrane nanoassemblies yielded multicompartment nanoparticles
with a dense core and a porous periphery of aqueous channels. Synergistic activities of nanodrugs and interaction of nanocarriers with a chosen cellular model was studied in relation to receptor
targeting and intracellular signaling pathways in neurodegeneration/neuroregeneration.

[1] A. Angelova, A., Angelovet al., Journal of Molecular Liquids, 2019, 279, 518 523 ; 
[2] M. Rakotoarisoa, B. Angelov et al., ACS Omega 2019,4, 3061 3073 ; 
[3] A. Angelova, M. Drechsler et al., ACS Omega, 2018, 3, 3235 3247 ; 
[4] B. Angelov, V. M. Garamus et al., Journal of Molecular Liquids, 2017, 235 8389 ; 
[5] B. Angelov, A Angelova et al., ACS Nano, 2014, 8, 5216 5226 ; 
[6] A. Angelova, B. Angelov et al., J. Inorg Organomet Polym. 2015, 25, 214 232.